Visualization of retinal vascular structure and perfusion with a nonconfocal adaptive optics scanning light ophthalmoscope. J Opt Soc Am A Opt Image Sci Vis 2014 Mar 01;31(3):569-79
Date
04/03/2014Pubmed ID
24690655Pubmed Central ID
PMC4465430DOI
10.1364/JOSAA.31.000569Scopus ID
2-s2.0-84898073904 (requires institutional sign-in at Scopus site) 66 CitationsAbstract
Imaging of the retinal vascular structure and perfusion was explored by confocal illumination and nonconfocal detection in an adaptive optics scanning light ophthalmoscope (AOSLO), as an extension of the work by Chui et al. [Biomed. Opt. Express 3, 2537 (2012)]. Five different detection schemes were evaluated at multiple retinal locations: circular mask, annular mask, circular mask with filament, knife-edge, and split-detector. Given the superior image contrast in the reflectance and perfusion maps, the split-detection method was further tested using pupil apodization, polarized detection, and four different wavelengths. None of these variations provided noticeable contrast improvement. The noninvasive visualization of capillary flow and structure provided by AOSLO split-detection shows great promise for studying ocular and systemic conditions that affect the retinal vasculature.
Author List
Sulai YN, Scoles D, Harvey Z, Dubra AMESH terms used to index this publication - Major topics in bold
AdultBlood Vessels
Humans
Light
Male
Ophthalmoscopes
Pupil
Regional Blood Flow
Retina
