Comparison of continuous and intermittent vibration effects on rat-tail artery and nerve. Muscle Nerve 2006 Aug;34(2):197-204
Date
05/13/2006Pubmed ID
16691604DOI
10.1002/mus.20578Scopus ID
2-s2.0-33746743748 (requires institutional sign-in at Scopus site) 40 CitationsAbstract
Hand-transmitted vibration from powered-tools can cause peripheral vasospasm and neuropathy. A rat-tail model was used to investigate whether the pattern of vibration influenced the type and severity of tissue damage. The tails of awake rats were vibrated continuously or intermittently for a total of 4 hours at 60 HZ, 49 m/s(2). Nerves and arteries were harvested immediately or 24 hours after treatment. Tails subjected to intermittent vibration showed transiently increased sensitivity to thermal stimuli. Intermittent vibration caused the most nerve injury immediately and 24 hours after vibration. Continuous vibration invoked a persistent reduction in vascular lumen size. Compared to epinephrine-induced transient vacuolation in vascular smooth muscle cells, both continuous and intermittent vibration caused greater persistence of vacuoles, indicating a vibration-induced pathological process. All vibration groups exhibited elevated nitrotyrosine immunoreactivity indicative of free-radical damage. Pattern of vibration exposure may exert a major influence on the type of vibration injury.
Author List
Govindaraju SR, Curry BD, Bain JL, Riley DAMESH terms used to index this publication - Major topics in bold
AnimalsArteries
Axons
Behavior, Animal
Coloring Agents
Free Radicals
Male
Muscle, Smooth, Vascular
Myelin Sheath
Peripheral Nerves
Rats
Rats, Sprague-Dawley
Tail
Tolonium Chloride
Vibration
