Coordination of ATP production and consumption in brain: parallel regulation of cytochrome oxidase and Na+, K(+)-ATPase. Neurosci Lett 1992 Apr 13;138(1):188-92
Date
04/13/1992Pubmed ID
1328957DOI
10.1016/0304-3940(92)90502-xScopus ID
2-s2.0-0026535360 (requires institutional sign-in at Scopus site) 85 CitationsAbstract
Previous studies have shown that most neuronal ATP is produced by oxidative metabolism, and consumed by Na+,K(+)-ATPase. We hypothesized that the distribution of Na+,K(+)-ATPase in brain would correlate with that of the energy-producing enzyme, cytochrome oxidase (CO). We localized these enzymes in monkey hippocampus and striate cortex by histochemistry and immunohistochemistry. Their distributions were generally similar, although some differences were observed. We also studied regulation of enzyme levels, using monocular impulse blockage with tetrodotoxin (TTX) to alter neuronal activity in the visual system. Parallel changes in CO and Na+,K(+)-ATPase activity were induced in striate cortex. These results provide further evidence that neuronal energy demands regulate CO levels and distribution.
Author List
Hevner RF, Duff RS, Wong-Riley MTMESH terms used to index this publication - Major topics in bold
Adenosine TriphosphateAnimals
Electron Transport Complex IV
Hippocampus
Histocytochemistry
Homeostasis
Immunohistochemistry
Isoenzymes
Macaca fascicularis
Macaca radiata
Neurons
Reference Values
Sodium-Potassium-Exchanging ATPase
Tetrodotoxin
Visual Cortex
