Obesity, central adiposity and cardiometabolic risk factors in children and adolescents: a family-based study. Pediatr Obes 2014 Jun;9(3):e58-e62
Date
03/29/2014Pubmed ID
24677702Pubmed Central ID
PMC4114214DOI
10.1111/j.2047-6310.2014.218.xScopus ID
2-s2.0-84900452401 (requires institutional sign-in at Scopus site) 104 CitationsAbstract
OBJECTIVE: The objective of this study was to assess genetic and phenotypic correlations of obesity-related cardiometabolic risk factors in a family-based cohort.
METHODS: Anthropometric, body composition and biochemical measurements were collected on 999 members of 111 extended Midwestern US families of Northern European origin. Forward stepwise regression was used to identify which of Tanner stage, sex, Tanner stage by sex, body fat mass index, body fat percentage (dual-energy X-ray absorptiometry), visceral fat (VF)/subcutaneous fat (SubQF) (computed tomography scans for adults or magnetic resonance imaging for children), VF, SubQF, body mass index (BMI)% and waist to height ratio most influence homeostasis model assessment (HOMA), high-density lipoprotein cholesterol (HDL-c), plasma triglycerides (TG) and low-density lipoprotein cholesterol (LDL-c).
RESULTS: In children and adolescents, subcutaneous adiposity was the most significant covariate for HOMA (P < 0.001) and TG (P = 0.001), and BMI percentile for HDL-c (P = 0.002) and LDL-c (P < 0.001). In adults, waist-height ratio (P < 0.001), VF/SubQF ratio (P = 0.001) and BMI (P = 0.02) were most significant for HOMA; VF (P < 0.001) and BMI (P = 0.02) for TG and VF for LDL-c (P = 0.001).
CONCLUSION: Subcutaneous adiposity at the waist is a more significant predictor of metabolic syndrome traits in children and adolescents than it is in adults.
Author List
Ali O, Cerjak D, Kent JW, James R, Blangero J, Zhang YMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Body Composition
Body Mass Index
Cardiovascular Diseases
Child
Cholesterol, HDL
Cholesterol, LDL
Cohort Studies
Female
Humans
Insulin Resistance
Male
Metabolic Syndrome
Obesity, Abdominal
Phenotype
Predictive Value of Tests
Risk Assessment
Risk Factors
Triglycerides
Waist Circumference
