Effect of KCl infusion on renin secretory rates and aldosterone excretion in dogs. Am J Physiol 1975 Aug;229(2):370-5
Date
08/01/1975Pubmed ID
1163662DOI
10.1152/ajplegacy.1975.229.2.370Scopus ID
2-s2.0-0016720495 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
The effects of unilateral intrarenal arterial KCl infusion in dogs (12 mueq/kg per min) on bilateral renal function, renin secretory rates, and aldosterone excretion were studied. During KCl infusion, infused-side renal arterial plasma [K+] increased by 2.2 +/- 0.6 meq/liter. Systemic plasma [K+] simultaneously rose by 0.6 +/- 0.1 meq/liter. Plasma renin activity decreased 29 +/- 9%, and the decrease correlated with the increases in plasma [K+]. Renin secretory rate decreased bilaterally, the decrease being greater in each experiment on the infused side. Aldosterone excretion increased during KCl infusion by 72 +/- 17%, despite a decrease in plasma renin activity. With KCl infusion there was a bilateral increase in K+ excretion, and a positive correlation was observed between the net alterations in K+ and Na+ excretion. No significant alterations in systemic blood pressure, glomerular filtration rate, total renal blood flow, or intracortical renal blood flow distribution were observed. These studies suggest that K+ inhibits the release of renin by an intrarenal mechanism, which may be related to a K+-induced alteration in Na+ absorption.
Author List
Flamenbaum W, Kleinman JG, McNeil JS, Hamburger RJ, Kotchen TAMESH terms used to index this publication - Major topics in bold
AldosteroneAnimals
Blood Pressure
Dogs
Female
Glomerular Filtration Rate
Kidney
Potassium
Potassium Chloride
Regional Blood Flow
Renin
Secretory Rate
Sodium
