Antineoplastic effects of gallium nitrate on human medulloblastoma in vivo. Pediatr Neurol 1992;8(5):323-7
Date
09/01/1992Pubmed ID
1418174DOI
10.1016/0887-8994(92)90083-bScopus ID
2-s2.0-0026441225 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Gallium nitrate possesses antineoplastic activity against certain solid tumors and has been demonstrated to be an effective agent in reducing cell proliferation and DNA synthesis in the medulloblastoma Daoy cell line in vitro. In prior studies, gallium inhibited the cellular uptake of 59Fe by brain tumor cells; however, this block in 59Fe uptake was variable and closely paralleled the inhibitory effects of gallium on cell growth. In vivo trials now have been conducted and have yielded some promising results. Nude mice received intradermal injections of medulloblastoma Daoy and then allowed to grow tumors. When the mice had developed at least one tumor between 9 to 10 mm in diameter, a 10-day course of intraperitoneal gallium nitrate injections was initiated. Gallium nitrate treatment reduced overall tumor growth rate and reduced actual tumor size. Nephrotoxicity was severe, but may be preventable by continuous gallium infusion and use of diuretics and hyperhydration.
Author List
Whelan HT, Schmidt MH, Anderson GS, Chan BK, Hunter K, Kubacki D, Segura AD, Chitambar CRAuthor
Annette D. Segura MD Adjunct Assistant Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntineoplastic Agents
Blood Urea Nitrogen
Cell Division
Cell Survival
Cerebellar Neoplasms
Cerebellum
Gallium
Medulloblastoma
Mice
Mice, Nude
Neoplasm Transplantation
