Faculty Collaboration Database

Immune suppression attenuates hypertension and renal disease in the Dahl salt-sensitive rat. Hypertension 2006 Jul;48(1):149-56

Date

06/07/2006

Pubmed ID

16754791

DOI

10.1161/01.HYP.0000228320.23697.29

Scopus ID

2-s2.0-33746016265 (requires institutional sign-in at Scopus site)   155 Citations

Abstract

Experiments were performed to determine the importance of activation or infiltration of immune cells in the kidney during the development of hypertension and renal disease in Dahl salt-sensitive rats (SS/Mcw) fed a 4.0% NaCl diet. Compared with vehicle-treated rats, chronic administration of mycophenolate mofetil ([MMF] 30 mg/kg per day, IP), an immunosuppressive agent that has cytostatic effects on T and B cells, decreased cell-specific markers of T and B cells by 50% to 60% in the kidneys of SS/Mcw rats (n=5 per group). Further studies were performed on Dahl SS/Mcw rats, which were instrumented with chronic indwelling catheters and studied after 3 weeks on the 4.0% NaCl diet. Rats were administered MMF or 5% dextrose vehicle daily during the 3-week period of high NaCl intake. Mean arterial blood pressure in the rats administered MMF (122+/-2 mm Hg; n=11) was significantly decreased compared with vehicle-treated rats (139+/-4 mm Hg; n=9). Furthermore, the rate of protein (112+/-13 mg per day) and albumin excretion (15+/-3 mg per day) in the MMF-treated rats was significantly lower than the protein and albumin excretion rate in vehicle-treated rats (167+/-25 and 31+/-7 mg per day, respectively). Creatinine clearance and body weight were not different between the groups, averaging 0.52+/-0.08 mL/min per gram kidney weight and 322+/-10 g, respectively, in the MMF-treated group. These experiments indicate that the activation of the immune system or renal infiltration of immune cells plays an important role in the development of hypertension and renal disease in Dahl SS/Mcw rats consuming an elevated NaCl diet.

Author List

Mattson DL, James L, Berdan EA, Meister CJ

MESH terms used to index this publication - Major topics in bold

Albumins
Animals
Blood Pressure
Creatinine
Hypertension
Immunosuppressive Agents
Kidney
Kidney Diseases
Male
Mycophenolic Acid
Proteins
Rats
Rats, Inbred Dahl
Sodium Chloride