Adiponectin and resistin in the neonatal rat: effects of dexamethasone and hypoxia. Endocrine 2006 Apr;29(2):341-4
Date
06/21/2006Pubmed ID
16785610Pubmed Central ID
PMC1481650DOI
10.1385/ENDO:29:2:341Scopus ID
2-s2.0-33746211276 (requires institutional sign-in at Scopus site) 23 CitationsAbstract
Hypoxia is a common neonatal stress that induces insulin resistance and a decrease in body weight gain. Dexamethasone is often used to treat neonatal cardiopulmonary disease, and also leads to insulin resistance and a decrease in body weight gain. The current study addressed the hypothesis that serum concentrations of the adipokines adiponectin and/or resistin are altered during hypoxia and/or dexamethasone therapy in neonatal rats. Rat pups with their lactating dams were exposed to hypoxia (11% O2) from birth and treated with a tapering regimen of dexamethasone from postnatal day (PD) 3-6. Serum adiponectin and resistin were measured on PD7. Hypoxia and dexamethasone independently decreased body weight gain and increased adiponectin levels. The combination of hypoxia and dexamethasone did not further increase adiponectin. Dexamethasone caused a small increase in resistin in normoxic pups, which may facilitate the hyperinsulemic- normoglycemic state we previously described. We also conclude that adiponectin is increased during hypoxia in response to a decrease in the sensitivity to insulin.
Author List
Raff H, Bruder EDAuthor
Hershel Raff PhD Professor in the Academic Affairs department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdiponectinAnimals
Animals, Newborn
Anti-Inflammatory Agents, Non-Steroidal
Atherosclerosis
Body Weight
Dexamethasone
Hypoxia
Insulin Resistance
Rats
Rats, Sprague-Dawley
Resistin
