Merocyanine-sensitized photoinactivation of enveloped viruses. Blood Cells 1992;18(1):117-27; discussion 128
Date
01/01/1992Pubmed ID
1617187Scopus ID
2-s2.0-0026595104 (requires institutional sign-in at Scopus site) 41 CitationsAbstract
A wide range of enveloped viruses, including human herpes simplex virus type 1, human cytomegalovirus, human T cell leukemia/lymphoma virus type I, human immunodeficiency virus type 1, Sindbis virus, and Friend erythroleukemia virus, are highly susceptible to merocyanine 540 (MC 540)-sensitized photoinactivation. By contrast, human pluripotent hematopoietic stem cells, red cells, factor VIII, and von Willebrand factor are much less sensitive. This suggests that MC 540 may be useful for the inactivation of enveloped viruses in blood and blood products. The dye has a low acute systemic toxicity, is rapidly eliminated from the blood stream, and has little or no mutagenic potential. The currently available data support the view that MC 540-sensitized photo-inactivation interferes with early events in the infectious process, notably the ability of the virus to adhere to and penetrate its host cell. The viral envelope is a major target of photodynamic damages which appear to be mediated at least in part by singlet molecular oxygen.
Author List
Sieber F, O'Brien JM, Gaffney DKAuthor
Fritz Sieber PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntiviral Agents
Blood Proteins
Bone Marrow Purging
Cell Membrane
Erythrocyte Membrane
Humans
Liposomes
Mice
Oxygen
Photochemistry
Pyrimidinones
Radiation-Sensitizing Agents
Rats
Singlet Oxygen
Virus Physiological Phenomena
Virus Replication
Viruses
