Faculty Collaboration Database

Computerized evaluation of electroencephalographic changes accompanying exchange transfusion in Reye's syndrome. Electroencephalogr Clin Neurophysiol 1977 Apr;42(4):466-79

Date

04/01/1977

Pubmed ID

66130

DOI

10.1016/0013-4694(77)90210-3

Scopus ID

2-s2.0-0017357465 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

The EEGs of 7 children with Reye's syndrome (fatty liver and encephalopathy) were continuously recorded on magnetic tape for times ranging from 12 to 80 h. During these times the major therapy consisted of exchange blood transfusions. The tapes were automatically processed on a LINC-8 computer using a peak-detection algorithm. The main parameters investigated were the delta and theta indices, the mean EEG frequency, the mean peak-to-peak amplitude, and the frequency versus amplitude characteristics of the delta waves. In 5 patients who responded to therapy, a marked decrease in the delta activity and an increase in mean frequency were noted subsequent to exchange transfusions. In all 5 cases the delta waves exhibited a similar pattern of decreasing amplitude and increasing frequency following therapy. However, in 2 patients with a fatal outcome, no favorable EEG response was observed during treatment, and a simultaneous decline in both delta frequency and delta amplitude was noted as the clinical condition worsened. The results of this study indicate that continuous EEG monitoring in Reye's syndrome may be an important clinical adjunct in evaluating the effectiveness of exchange transfusion therapy and in signaling the need for further treatment.

Author List

Barr RE, Ackmann JJ, Harrington GJ, Varma RR, Lewis JD, Casper JT

MESH terms used to index this publication - Major topics in bold

Adolescent
Ammonia
Animals
Aspartate Aminotransferases
Chick Embryo
Child
Child, Preschool
Coma
Computers
Electroencephalography
Exchange Transfusion, Whole Blood
Female
Humans
Male
Monitoring, Physiologic
Reye Syndrome