Faculty Collaboration Database

Tumors with intrahepatic bile duct differentiation in cirrhosis: implications on outcomes after liver transplantation. Transplantation 2015 Jan;99(1):151-7

Date

07/17/2014

Pubmed ID

25029385

DOI

10.1097/TP.0000000000000286

Scopus ID

2-s2.0-84920278093 (requires institutional sign-in at Scopus site)   68 Citations

Abstract

BACKGROUND: The role of liver transplantation (LT) in the management of cirrhotic patients with tumors exhibiting intrahepatic bile duct differentiation remains controversial. The objective of this study was to characterize the spectrum of these tumors and analyze post-LT outcomes.

METHODS: Retrospective pathology database search of explant histology analysis of liver transplants between April 1993 and November 2013.

RESULTS: Thirty-two patients were analyzed, 75% were men with a mean age of 60 years. Seven patients had nodules demonstrating intrahepatic cholangiocarcinoma (I-CCA), nine had I-CCA nodules occurring concomitantly with hepatocellular carcinoma (HCC), and 16 had mixed HCC-CCA nodules. The median number of tumors was 1 and size was 2.5 cm. Overall patient survival post-LT at 1 and 5 years was 71% and 57%, respectively. Patients within Milan criteria, especially with I-CCA features, showed a 5-year tumor recurrence rate (10%) and 5-year survival rate (78%) comparable with other patients having HCC within Milan criteria.

CONCLUSION: This series showed that patients with CCA within Milan criteria may be able to achieve acceptable long-term post-LT survival.

Author List

Facciuto ME, Singh MK, Lubezky N, Selim MA, Robinson D, Kim-Schluger L, Florman S, Ward SC, Thung SN, Fiel M, Schiano TD

MESH terms used to index this publication - Major topics in bold

Bile Duct Neoplasms
Bile Ducts, Intrahepatic
Carcinoma, Hepatocellular
Cell Differentiation
Cholangiocarcinoma
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Liver Cirrhosis
Liver Neoplasms
Liver Transplantation
Male
Middle Aged
Neoplasm Recurrence, Local
Neoplasms, Complex and Mixed
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome