Allogeneic bone marrow chimerism in germ-free mice. IV. Therapy of "Hodgkin's-like" reticulum cell sarcoma in SJL mice. Transplantation 1976 Jan;21(1):12-6
Date
01/01/1976Pubmed ID
1108322DOI
10.1097/00007890-197601000-00003Scopus ID
2-s2.0-0017293903 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
"Hodgkin's-like reticulum cell sarcoma develops spontaneously in most SJL mice. Germ-free and conventional SJL mice bearing advanced reticulum cell sarcoma were treated with X-irradiation and transplantation of bone marrow from SJL or C3H/He donors. The 120-day survival rate of germ-free mice receiving allogeneic bone marrow (70%) exceeded that of all control groups; more importantly, germ-free mice that survived more than 4 months after treatment with allogeneic cells had no evidence of neoplastic lesions when killed. The germ-free environment effectively prevented graft-versus-host disease that was lethal to conventional mice. The results of these experiments offer additional evidence that bone marrow transplantation can be used as a therapeutic tool for spontaneous murine neoplasms.
Author List
Truitt RL, Pollard MAuthor
Robert L. Truitt PhD Emeritus Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBone Marrow Cells
Bone Marrow Transplantation
Germ-Free Life
Lymphoma, Non-Hodgkin
Mice
Mice, Inbred C3H
Mice, Inbred Strains
Radiation Chimera
Transplantation, Homologous
