Modulation by thiols of the merocyanine 540-sensitized photolysis of leukemia cells, red cells, and herpes simplex virus type 1. Photochem Photobiol 1991 Jan;53(1):85-92
Date
01/01/1991Pubmed ID
1851305DOI
10.1111/j.1751-1097.1991.tb08471.xScopus ID
2-s2.0-0025982315 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
This paper reports on the role of endogenous and exogenous thiols in the merocyanine 540 (MC 540)-sensitized photoirradiation of L1210 leukemia cells, human erythrocytes, and human Herpes simplex virus type 1. Several measures taken to decrease the intracellular content of glutathione enhanced the cells' sensitivity to MC 540-sensitized photoirradiation while stimulation of glutathione biosynthesis or supplementation of the extracellular or extraviral thiol content decreased the photosensitivity of cells and viruses. Taken together, these data suggest that endogenous and exogenous thiols can modulate the sensitivity of cells and enveloped viruses to MC 540-sensitized photoirradiation. They also pose new questions as to the mechanism of MC 540-sensitized photolysis.
Author List
Gaffney DK, O'Brien JM, Sieber FAuthor
Fritz Sieber PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCell Line
Erythrocytes
Glutathione
Humans
Leukemia L1210
Light
Mice
Pyrimidinones
Radiation-Sensitizing Agents
Simplexvirus
Sulfhydryl Compounds
