Faculty Collaboration Database

miR-21 in ischemia/reperfusion injury: a double-edged sword? Physiol Genomics 2014 Nov 01;46(21):789-97

Date

08/28/2014

Pubmed ID

25159851

Pubmed Central ID

PMC4280148

DOI

10.1152/physiolgenomics.00020.2014

Scopus ID

2-s2.0-84908453071 (requires institutional sign-in at Scopus site)   97 Citations

Abstract

MicroRNAs (miRNAs or miRs) are endogenous, small RNA molecules that suppress expression of targeted mRNA. miR-21, one of the most extensively studied miRNAs, is importantly involved in divergent pathophysiological processes relating to ischemia/reperfusion (I/R) injury, such as inflammation and angiogenesis. The role of miR-21 in renal I/R is complex, with both protective and pathological pathways being regulated by miR-21. Preconditioning-induced upregulation of miR-21 contributes to the protection against subsequent renal I/R injury through the targeting of genes such as the proapoptotic gene programmed cell death 4 and interactions between miR-21 and hypoxia-inducible factor. Conversely, long-term elevation of miR-21 may be detrimental to the organ by promoting the development of renal interstitial fibrosis following I/R injury. miR-21 is importantly involved in several pathophysiological processes related to I/R injury including inflammation and angiogenesis as well as the biology of stem cells that could be used to treat I/R injury; however, the effect of miR-21 on these processes in renal I/R injury remains to be studied.

Author List

Xu X, Kriegel AJ, Jiao X, Liu H, Bai X, Olson J, Liang M, Ding X

Authors

Xiaowen Bai PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin
Jessica Olson PhD Director, Associate Professor in the Institute for Health and Humanity department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Cell Survival
Fibrosis
Gene Expression Regulation
Humans
Hypoxia
Inflammation
Ischemia
Ischemic Preconditioning
Kidney
MicroRNAs
Neovascularization, Physiologic
Reperfusion Injury
Stem Cell Transplantation