Faculty Collaboration Database

A planning comparison of 7 irradiation options allowed in RTOG 1005 for early-stage breast cancer. Med Dosim 2015;40(1):21-5

Date

08/27/2014

Pubmed ID

25155215

Pubmed Central ID

PMC4654615

DOI

10.1016/j.meddos.2014.06.007

Scopus ID

2-s2.0-84922982708 (requires institutional sign-in at Scopus site)   27 Citations

Abstract

This study compared the 7 treatment plan options in achieving the dose-volume criteria required by the Radiation Therapy Oncology Group (RTOG) 1005 protocol. Dosimetry plans were generated for 15 representative patients with early-stage breast cancer (ESBC) based on the protocol-required dose-volume criteria for each of the following 7 treatment options: 3D conformal radiotherapy (3DCRT), whole-breast irradiation (WBI) plus 3DCRT lumpectomy boost, 3DCRT WBI plus electron boost, 3DCRT WBI plus intensity-modulated radiation therapy (IMRT) boost, IMRT WBI plus 3DCRT boost, IMRT WBI plus electron boost, IMRT WBI plus IMRT boost, and simultaneous integrated boost (SIB) with IMRT. A variety of dose-volume parameters, including target dose conformity and uniformity and normal tissue sparing, were compared for these plans. For the patients studied, all plans met the required acceptable dose-volume criteria, with most of them meeting the ideal criteria. When averaged over patients, most dose-volume goals for all plan options can be achieved with a positive gap of at least a few tenths of standard deviations. The plans for all 7 options are generally comparable. The dose-volume goals required by the protocol can in general be easily achieved. IMRT WBI provides better whole-breast dose uniformity than 3DCRT WBI does, but it causes no significant difference for the dose conformity. All plan options are comparable for lumpectomy dose uniformity and conformity. Patient anatomy is always an important factor when whole-breast dose uniformity and conformity and lumpectomy dose conformity are considered.

Author List

Chen GP, Liu F, White J, Vicini FA, Freedman GM, Arthur DW, Li XA

Author

Guang-Pei Chen PhD Associate Professor in the Radiation Oncology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Breast Neoplasms
Female
Humans
Internationality
Neoplasm Staging
Practice Guidelines as Topic
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Conformal
Reproducibility of Results
Sensitivity and Specificity
Software Validation