Beyond vasodilatation: non-vasomotor roles of epoxyeicosatrienoic acids in the cardiovascular system. Trends Pharmacol Sci 2007 Jan;28(1):32-8
Date
12/08/2006Pubmed ID
17150260DOI
10.1016/j.tips.2006.11.002Scopus ID
2-s2.0-33845944050 (requires institutional sign-in at Scopus site) 75 CitationsAbstract
Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid by cytochrome P450 epoxygenases, are potent vasodilators that function as endothelium-derived hyperpolarizing factors in some vascular beds. EETs are rapidly metabolized by soluble epoxide hydrolase to form dihydroxyeicosatrienoic acids (DHETs). Recent reports indicate that EETs have several important non-vasomotor regulatory roles in the cardiovascular system. EETs are potent anti-inflammatory agents and might function as endogenous anti-atherogenic compounds. In addition, EETs and DHETs might stimulate lipid metabolism and regulate insulin sensitivity. Thus, pharmacological inhibition of soluble epoxide hydrolase might be useful not only for hypertension but also for abating atherosclerosis, diabetes mellitus and the metabolic syndrome. Finally, although usually protective in the systemic circulation, EETs might adversely affect the pulmonary circulation.
Author List
Larsen BT, Campbell WB, Gutterman DDAuthors
William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinDavid Gutterman MD Emeritus Professor in the Medicine department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
8,11,14-Eicosatrienoic AcidAnimals
Arachidonic Acid
Atherosclerosis
Cardiovascular System
Humans
Hypertension, Pulmonary
Insulin Resistance
Metabolic Syndrome
Molecular Structure
Vasodilation
