Spontaneous elimination of nerve terminals from the endplates of developing skeletal myofibers. Brain Res 1977 Oct 07;134(2):279-85
Date
10/07/1977Pubmed ID
890492DOI
10.1016/0006-8993(77)91073-3Scopus ID
2-s2.0-0017643418 (requires institutional sign-in at Scopus site) 89 CitationsAbstract
The development of the motor innervation of a skeletal muscle was examined in the soleus muscles of young rats. At 11 days after birth, nearly three-quarters of the endplates of individual myofibers were innervated by more than one silver stained axon. Four days later, only about 9% of the endplates remained innervated by two or more terminals. The dramatic reduction in the number of axon terminals appeared to result in large measure from the retraction of all but one of the multiple terminals. An axon interpreted as undergoing retraction was characterized by a terminal oval enlargement believed to be the site of disassembly of the fiber.
Author List
Riley DAAuthor
Danny Riley PhD Emeritus Professor in the Cell Biology Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgingAnimals
Axons
Motor Endplate
Muscle Development
Muscles
Nerve Endings
Nerve Fibers
Neuromuscular Junction
Rats
