Medical College of Wisconsin
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Epoxygenase eicosanoids: synthesis of tetrahydrofuran-diol metabolites and their vasoactivity. Bioorg Med Chem Lett 2007 May 01;17(9):2634-8

Date

02/13/2007

Pubmed ID

17293113

Pubmed Central ID

PMC1950572

DOI

10.1016/j.bmcl.2007.01.096

Scopus ID

2-s2.0-34047164656 (requires institutional sign-in at Scopus site)   17 Citations

Abstract

Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from D-(+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries.

Author List

Falck JR, Reddy LM, Byun K, Campbell WB, Yi XY

Author

William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Arteries
Cattle
Chemistry, Pharmaceutical
Dose-Response Relationship, Drug
Drug Design
Eicosanoids
Furans
Models, Chemical
Molecular Conformation
Oxygenases
Stereoisomerism
Vasodilation
Vasodilator Agents