Faculty Collaboration Database

Recovery from acute renal failure predisposes hypertension and secondary renal disease in response to elevated sodium. Am J Physiol Renal Physiol 2007 Jul;293(1):F269-78

Date

05/18/2007

Pubmed ID

17507599

DOI

10.1152/ajprenal.00279.2006

Scopus ID

2-s2.0-34548040204 (requires institutional sign-in at Scopus site)   93 Citations

Abstract

Recovery of renal function is a well-characterized feature of models of acute renal failure; however, more recent studies have reported a predisposition to chronic renal disease. This study sought to determine the susceptibility to sodium-dependent hypertension following recovery from ischemic acute renal failure. Following ischemia-reperfusion (I/R) injury, rats were allowed to recover for 35 days on a 0.4% salt diet, then were switched to 4.0% salt diet for an additional 28 days. Blood pressure was significantly increased in postischemic rats switched to high-sodium diet at day 35 (19 +/- 9 mmHg) compared with postischemic rats maintained on low-sodium diet. Plasma renin activity and creatinine clearance were not affected by I/R injury. The ischemic injury combined with transfer to 4.0% salt diet resulted in marked renal hypertrophy characterized by interstitial cellular deposition, tubular dilation, and enhanced rates of albumin excretion. Glomerular structure was altered in post-I/R rats switched to high-sodium diet but not in those maintained on low-sodium diets. When rats were acclimated to high-sodium diet before I/R injury, the early injury was similar to that observed in animals acclimated to low-sodium diet, and these animals progressed rapidly toward chronic kidney disease, as evidenced by advancement of albuminuria. These data suggest that the recovery from acute I/R injury is not complete, compromises Na homeostasis, and predisposes hypertension and secondary renal disease.

Author List

Spurgeon-Pechman KR, Donohoe DL, Mattson DL, Lund H, James L, Basile DP

MESH terms used to index this publication - Major topics in bold

Acute Kidney Injury
Aging
Animals
Blood Pressure
Capillaries
Catecholamines
Creatinine
Cyclosporine
Diet
Disease Progression
Hypertension, Renal
Immunohistochemistry
Immunosuppressive Agents
Kidney Failure, Chronic
Kidney Glomerulus
Kidney Tubules
Male
Organ Size
Rats
Rats, Sprague-Dawley
Renal Circulation
Renin
Sodium
Sodium, Dietary