Soluble CD14 is associated with markers of vascular dysfunction in bariatric surgery patients. Metab Syndr Relat Disord 2015 Apr;13(3):119-24
Date
01/07/2015Pubmed ID
25562385DOI
10.1089/met.2014.0111Scopus ID
2-s2.0-84925348671 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
BACKGROUND: Chronic endotoxemia has been proposed to contribute to obesity-related complications. We aimed to investigate the potential impact of lipopolysaccharide (LPS) and subsequent monocyte activation measured as soluble CD14 (sCD14) on markers of vascular dysfunction in obese subjects undergoing bariatric surgery.
METHODS: This was a prospective study of 49 obese patients and 17 controls, assessed by plasma levels of LPS, sCD14, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA).
RESULTS: Levels of ADMA were increased in obese subjects compared to controls, but were not significantly reduced after bariatric surgery. In obese subjects at baseline, there was a significant trend to increasing levels of ADMA and SDMA through tertiles of sCD14 and decreasing levels of both markers through tertiles of LPS. In models adjusting for age and gender, sCD14 but not LPS remained independently associated with ADMA and SDMA. For every 10% age- and gender-adjusted increase in sCD14, ADMA increased 0.031 μM (5.6%), whereas SDMA increased 0.039 μM (10.8%).
CONCLUSIONS: Our results suggest that monocyte activation as measured by sCD14 is associated with obesity-related vascular dysfunction, whereas potential upstream triggers including microbial products should be investigated in future studies.
Author List
Trøseid M, Nestvold TK, Nielsen EW, Thoresen H, Seljeflot I, Lappegård KTMESH terms used to index this publication - Major topics in bold
Adipose TissueAdult
Age Factors
Arginine
Bariatric Surgery
Biomarkers
Female
Humans
Lipopolysaccharide Receptors
Lipopolysaccharides
Male
Middle Aged
Monocytes
Obesity
Prospective Studies
Risk Factors
Sex Factors
Vascular Diseases
