Faculty Collaboration Database

Diuretic therapies in low renin and normal renin essential hypertension. Clin Pharmacol Ther 1977 Jul;22(1):14-20

Date

07/01/1977

Pubmed ID

326459

DOI

10.1002/cpt197722114

Scopus ID

2-s2.0-0017736404 (requires institutional sign-in at Scopus site)   13 Citations

Abstract

This study was designed to compare the effectiveness of spironolactone, hydrochlorothiazide, and combined spironolactone-hydrochlorothiazide therapy in patients with low renin and those with normal renin essential hypertension. Patients with low renin hypertension had a greater hypotensive response to each regimen (p less than 0.001). Low renin patients responded equally to both spironolactone and to hydrochlorothiazide, and in low renin but not in normal renin patients reduction of blood pressure correlated with weight loss. These results suggest that a volume factor, not specifically related to increased mineralocorticoid production, contributes to the pathogenesis of low renin essential hypertension.

Author List

Brooks CS, Johnson CA, Kotchen JM, Kotchen TA

MESH terms used to index this publication - Major topics in bold

Adult
Blood Pressure
Body Weight
Clinical Trials as Topic
Double-Blind Method
Drug Combinations
Female
Furosemide
Humans
Hydrochlorothiazide
Hypertension
Male
Middle Aged
Potassium
Renin
Spironolactone
Uric Acid