Faculty Collaboration Database

Mineral trioxide aggregate material use in endodontic treatment: a review of the literature. Dent Mater 2008 Feb;24(2):149-64

Date

06/26/2007

Pubmed ID

17586038

DOI

10.1016/j.dental.2007.04.007

Scopus ID

2-s2.0-37349022459 (requires institutional sign-in at Scopus site)   363 Citations

Abstract

OBJECTIVE: The purpose of this paper was to review the composition, properties, biocompatibility, and the clinical results involving the use of mineral trioxide aggregate (MTA) materials in endodontic treatment.

METHODS: Electronic search of scientific papers from January 1990 to August 2006 was accomplished using PubMed and Scopus search engines (search terms: MTA, GMTA, WMTA, mineral AND trioxide AND aggregate).

RESULTS: Selected exclusion criteria resulted in 156 citations from the scientific, peer-reviewed dental literature. MTA materials are derived from a Portland cement parent compound and have been demonstrated to be biocompatible endodontic repair materials, with its biocompatible nature strongly suggested by its ability to form hydroxyappatite when exposed to physiologic solutions. With some exceptions, MTA materials provide better microleakage protection than traditional endodontic repair materials using dye, fluid filtration, and bacterial penetration leakage models. In both animal and human studies, MTA materials have been shown to have excellent potential as pulp-capping and pulpotomy medicaments but studies with long-term follow-up are limited. Preliminary studies suggested a favorable MTA material use as apical and furcation restorative materials as well as medicaments for apexogenesis and apexification treatments; however, long-term clinical studies are needed in these areas.

CONCLUSION: MTA materials have been shown to have a biocompatible nature and have excellent potential in endodontic use. MTA materials are a refined Portland cement material and the substitution of Portland cement for MTA products is presently discouraged. Existing human studies involving MTA materials are very promising, however, insufficient randomized, double-blind clinical studies of sufficient duration exist involving MTA for all of its clinical indications. Further clinical studies are needed in these areas.

Author List

Roberts HW, Toth JM, Berzins DW, Charlton DG

Authors

David Berzins BS,PhD Graduate Program Director for Dental Biomaterials in the General Dental Sciences/Dental Biomaterials department at Marquette University
Jeffrey M. Toth PhD Associate Dean for Research in the School of Dentistry department at Marquette University

MESH terms used to index this publication - Major topics in bold

Aluminum Compounds
Animals
Biocompatible Materials
Calcium Compounds
Dental Cements
Dental Leakage
Dental Pulp Capping
Drug Combinations
Durapatite
Humans
Oxides
Pulpotomy
Randomized Controlled Trials as Topic
Root Canal Filling Materials
Silicates