Faculty Collaboration Database

Extracellular volume fraction in dilated cardiomyopathy patients without obvious late gadolinium enhancement: comparison with healthy control subjects. Int J Cardiovasc Imaging 2015 Jun;31 Suppl 1:115-22

Date

01/31/2015

Pubmed ID

25634119

DOI

10.1007/s10554-015-0595-0

Scopus ID

2-s2.0-84930752363 (requires institutional sign-in at Scopus site)   34 Citations

Abstract

To evaluate whether the extracellular volume fraction (ECV) measured using cardiac magnetic resonance (CMR) imaging can detect myocardial tissue changes in dilated cardiomyopathy (DCM) without late gadolinium enhancement (LGE). Forty-one DCM patients and 10 healthy volunteers underwent pre- and post-T1 mapping using a modified Look-Locker Inversion recovery sequence, LGE, and cine MRI on a 3-T CMR system. LGE-MR findings were used to divide DCM patients into two groups: Group A had no apparent LGE, and Group B had LGE apparent in at least one segment. The ECV of the left ventricle (LV) myocardium (16 segments) was calculated in the short-axis view as follows: ECV = [(ΔR1 of myocardium/ΔR1 of LV blood pool)] × (1 - hematocrit), where R1 = 1/T1, ΔR1 = post-contrast R1 - pre-contrast R1. The LV ejection fraction (LVEF) was obtained from cine MRI images. The mean myocardial ECV in LGE (-) segments in Group A + B was compared to that of controls. The mean myocardial ECV in Group A was compared to that of LGE (-) segments in Group B. The correlation between LV systolic function and the mean myocardial ECV of the whole myocardium was evaluated in all groups. Among the 41 DCM patients, 22 were in Group A, and 19 were in Group B. The mean ECV of DCM patents (n = 41, 568 segments, 30.7 % ± 5.9) was significantly higher (P < 0.001) than that of the control group (n = 10, 157 segments, 25.6 % ± 3.2). The ECV was inversely related to LVEF in Group A (r = -0.551, P = 0.008), Group B (r = -0.525, P = 0.021), and Group A + B (r = -0.550, P < 0.001). The ECV measured by MRI could be a useful parameter in evaluating diffuse myocardial changes in DCM patients.

Author List

Hong YJ, Park CH, Kim YJ, Hur J, Lee HJ, Hong SR, Suh YJ, Greiser A, Paek MY, Choi BW, Kim TH

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Aged, 80 and over
Cardiomyopathy, Dilated
Case-Control Studies
Contrast Media
Feasibility Studies
Female
Fibrosis
Heart Ventricles
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging, Cine
Male
Middle Aged
Organometallic Compounds
Predictive Value of Tests
Prospective Studies
Stroke Volume
Ventricular Function, Left
Young Adult