Resistance strength training exercise in children with spinal muscular atrophy. Muscle Nerve 2015 Oct;52(4):559-67
Date
01/20/2015Pubmed ID
25597614Pubmed Central ID
PMC4506899DOI
10.1002/mus.24568Scopus ID
2-s2.0-84935010763 (requires institutional sign-in at Scopus site) 68 CitationsAbstract
INTRODUCTION: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function.
METHODS: We evaluated feasibility, safety, and effects on strength and motor function of a home-based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks.
RESULTS: Nine children with SMA, aged 10.4 ± 3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain-free (99.8%), and no study-related adverse events occurred. Trends in improved strength and motor function were observed.
CONCLUSIONS: A 12-week supervised, home-based, 3-day/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA.
Author List
Lewelt A, Krosschell KJ, Stoddard GJ, Weng C, Xue M, Marcus RL, Gappmaier E, Viollet L, Johnson BA, White AT, Viazzo-Trussell D, Lopes P, Lane RH, Carey JC, Swoboda KJMESH terms used to index this publication - Major topics in bold
AdolescentChild
Child, Preschool
Female
Humans
Male
Motor Activity
Muscle Strength
Muscle, Skeletal
Muscular Atrophy, Spinal
Reflex
Reproducibility of Results
Resistance Training
Treatment Outcome
