Faculty Collaboration Database

Predictors of Recurrent Stroke in Patients with Ischemic Stroke: Comparison Study between Transesophageal Echocardiography and Cardiac CT. Radiology 2015 Aug;276(2):381-9

Date

02/19/2015

Pubmed ID

25692312

DOI

10.1148/radiol.15142300

Scopus ID

2-s2.0-84938690538 (requires institutional sign-in at Scopus site)   24 Citations

Abstract

PURPOSE: To investigate cardiac computed tomographic (CT) findings predictive of recurrent stroke in patients with ischemic stroke and determine the incremental risk stratification benefit of cardiac CT findings compared with transesophageal echocardiography (TEE) findings in patients with ischemic stroke.

MATERIALS AND METHODS: This single-center prospective study protocol was approved by the institutional review boards, and written informed consent was obtained from all patients. Among 548 consecutive patients, 374 patients with ischemic stroke (254 men and 120 women, with a mean age of 63.1 years) who underwent TEE and cardiac CT were prospectively enrolled in this study. TEE and cardiac CT images were assessed for cardioembolic sources, including thrombus, tumor, spontaneous echo contrast, valvular vegetation, atrial septal aneurysm, patent foramen ovale, and aortic plaque. The primary end point was stroke recurrence. Prognostic factors were assessed with Cox univariate and multivariate analysis. The integrated area under the receiver operating characteristic curve was calculated to compare the prognostic abilities of CT and TEE parameters.

RESULTS: During a median follow-up period of 433 days, there were a total of 28 recurrent stroke events. The TEE parameter of plaque complexity (hazard ratio, 13.512; 95% confidence interval: 3.668, 49.778; P < .001) and CT parameter of plaque complexity (hazard ratio, 32.538; 95% confidence interval: 7.544, 140.347; P < .001) were predictors of recurrent stroke. The time-dependent receiver operating characteristic curve analysis demonstrated no significant differences in prediction of recurrent stroke between TEE and CT parameters (integrated area under the receiver operating characteristic curve, 0.812 vs 0.840, respectively).

CONCLUSION: Complex aortic plaque evaluated with cardiac CT and TEE was associated with an increased risk of stroke recurrence in patients with ischemic stroke.

Author List

Lee K, Hur J, Hong SR, Suh YJ, Im DJ, Kim YJ, Hong YJ, Lee HJ, Kim YJ, Lee HS, Hong GR, Choi BW

MESH terms used to index this publication - Major topics in bold

Aged
Brain Ischemia
Cardiac Imaging Techniques
Echocardiography, Transesophageal
Female
Follow-Up Studies
Humans
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Recurrence
Risk Assessment
Stroke
Tomography, X-Ray Computed