Apnea, tachypnea, and hypotension elicited by cardiac vagal afferents. J Appl Physiol Respir Environ Exerc Physiol 1979 Aug;47(2):312-8
Date
08/01/1979Pubmed ID
468686DOI
10.1152/jappl.1979.47.2.312Scopus ID
2-s2.0-0018687645 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
The reflex effects of right and left ventricular distension, mediated by vagal afferents, were studied in mongrel dogs anesthetized with halothane or pentobarbital sodium on heart-lung bypass. Diaphragm electromyogram (D-EMG), systemic blood pressure, and left ventricular cardiogram were all measured during ventricular distension. After bilateral section of the stellate ganglia, distension of the left ventricle produced an apnea, or slowing of respiration and systemic hypotension, without a change in heart rate. A reflex decrease in the amplitude of the D-EMG occurred if the initial breathing rate was high; a decrease in frequency of the D-EMG bursts occurred if the initial rate was low. The left ventricular vagal afferents altering respiration had conduction velocities between 22 and 70 m/s, whereas those causing hypotension had conduction velocities less than 22 m/s. Distension of the right ventricle resulted in a significant tachypnea and systemic hypotension without a change in heart rate. The conduction velocities of the right ventricular vagal afferents causing both tachypnea and hypotension were less than 9 m/s. These reflex changes in respiration and blood pressure elicited by both right and left ventricular distension were eliminated with vagotomy.
Author List
Kostreva DR, Hopp FA, Zuperku EJ, Kampine JPMESH terms used to index this publication - Major topics in bold
Afferent PathwaysAnimals
Blood Pressure
Dogs
Evoked Potentials
Heart
Heart Rate
Reflex
Respiration
Vagus Nerve
Ventricular Function
