Faculty Collaboration Database

Pro-oxidant effect of vitamin E in cigarette smokers consuming a high polyunsaturated fat diet. Arterioscler Thromb Vasc Biol 2001 Jun;21(6):1029-33

Date

06/09/2001

Pubmed ID

11397715

DOI

10.1161/01.atv.21.6.1029

Scopus ID

2-s2.0-0035715111 (requires institutional sign-in at Scopus site)   74 Citations

Abstract

Dietary polyunsaturated fats and vitamin E are associated with reduced risk for atherosclerosis, but in smokers, they could promote lipid oxidation. Therefore, we examined the effects of a high polyunsaturated fat diet and vitamin E supplementation on measures of lipid oxidation in cigarette smokers. Ten subjects who smoked >1 pack of cigarettes per day were sequentially fed the following: a baseline diet in which the major fat source was olive oil, a diet in which the major fat source was high-linoleic safflower oil, and finally, the safflower oil diet plus 800 IU vitamin E per day. LDL oxidation lag time and rate and plasma total F(2)-isoprostanes and prostaglandin F(2alpha) (PGF(2alpha)) were determined after 3 weeks on each diet. The safflower oil diet increased total F(2)-isoprostanes from 53.0+/-7.2 to 116.2+/-11.2 nmol/L and PGF(2alpha) from 3.5+/-0.2 to 5.5+/-0.5 nmol/L, without changing LDL oxidation parameters. Addition of vitamin E prolonged mean LDL oxidation lag time but, paradoxically, further increased F(2)-isoprostanes to 188.2+/-10.9 nmol/L and PGF(2alpha) to 7.8+/-0.4 nmol/L. These data suggest that vitamin E may function as a pro-oxidant in cigarette smokers consuming a high polyunsaturated fat diet.

Author List

Weinberg RB, VanderWerken BS, Anderson RA, Stegner JE, Thomas MJ

MESH terms used to index this publication - Major topics in bold

Arteriosclerosis
Diet
Dietary Supplements
Dinoprost
F2-Isoprostanes
Fatty Acids, Unsaturated
Humans
Kinetics
Lipid Peroxidation
Lipoproteins, LDL
Oxidative Stress
Smoking
Vitamin E