Resolution of Crohn's disease and complex regional pain syndrome following treatment of paratuberculosis. World J Gastroenterol 2015 Apr 07;21(13):4048-62
Date
04/09/2015Pubmed ID
25852293Pubmed Central ID
PMC4385555DOI
10.3748/wjg.v21.i13.4048Scopus ID
2-s2.0-84923203385 (requires institutional sign-in at Scopus site) 27 CitationsAbstract
A cohort of family members with various chronic diseases including Crohn's disease, asthma, complex regional pain syndrome, hypothyroidism, type 1 diabetes mellitus, and lymphangiomatosis and/or evidence of infection by Mycobacterium avium subsp. paratuberculosis (MAP) are described in this series of case reports. MAP was cultured from the blood of three members affected by the first five diseases and there was accompanying elevated anti-MAP IgG in two members. The patient affected by the sixth disease has a markedly elevated anti-MAP titer. The two patients affected by the first four diseases have been treated with a combination of anti-MAP antibiotics and ultraviolet blood irradiation therapy with resolution of the disease symptomatology and inability to culture MAP in post treatment blood samples. These case reports of patients with MAP infections provide supportive evidence of a pathogenic role of MAP in humans.
Author List
Kuenstner JT, Chamberlin W, Naser SA, Collins MT, Dow CT, Aitken JM, Weg S, Telega G, John K, Haas D, Eckstein TM, Kali M, Welch C, Petrie TMESH terms used to index this publication - Major topics in bold
AdultAntitubercular Agents
Bacteriological Techniques
Biopsy
Child
Colonoscopy
Combined Modality Therapy
Complex Regional Pain Syndromes
Crohn Disease
Female
Humans
Male
Mycobacterium avium subsp. paratuberculosis
Paratuberculosis
Remission Induction
Treatment Outcome
Ultraviolet Therapy
Young Adult
