The use of plasma exchange in Hashimoto's encephalopathy: A case report and review of the literature. J Clin Apher 2015 Jun;30(3):188-92
Date
08/15/2014Pubmed ID
25116126DOI
10.1002/jca.21353Scopus ID
2-s2.0-84930867655 (requires institutional sign-in at Scopus site) 30 CitationsAbstract
Hashimoto's Encephalopathy (HE) is a very rare condition characterized by psychosis, seizures, cognitive fluctuations, and myoclonus. In a few published cases, plasma exchange has been used due to the theoretical removal of antithyroid peroxidase antibodies (anti-TPO), one of the postulated causes of the condition. We report a case of HE treated by plasma exchange where no clinical or neurophysiologic improvement was observed despite documented reduction of the anti-TPO antibody to levels below the limits of laboratory detection. We discuss these findings in the context of the known literature for this disease process.
Author List
Cook MK, Malkin M, Karafin MSMESH terms used to index this publication - Major topics in bold
AutoantibodiesBlood Component Removal
Cognition Disorders
Encephalitis
Female
Hashimoto Disease
Humans
Immunoglobulins, Intravenous
Iodide Peroxidase
Middle Aged
Paranoid Disorders
Plasma Exchange
Plasmapheresis
Status Epilepticus
Steroids
