Tumorigenicity and metabolism of 1-nitropyrene in A/J mice. Carcinogenesis 1984 Nov;5(11):1449-52
Date
11/01/1984Pubmed ID
6488469DOI
10.1093/carcin/5.11.1449Scopus ID
2-s2.0-0021715043 (requires institutional sign-in at Scopus site) 93 CitationsAbstract
Four groups of 28-32 male and female A/J mice were given i.p. injections of either trioctanoin or 1-nitropyrene in trioctanoin such that the total doses of 1-nitropyrene were 0.71 mmol/kg, 2.14 mmol/kg, or 6.44 mmol/kg. The mean number of lung tumors/mouse was 1.3 +/- 1.0 in the group treated with 6.44 mmol/kg of 1-nitropyrene compared with 0.3 +/- 0.6 in the trioctanoin group (p less than 0.001). Combined tumor incidence was not significant compared with controls in the two lower dose groups. Cultured explants of A/J mouse lung, and 9000 g supernatant of A/J mouse lung and liver, metabolized [14C]1-nitropyrene to 4,5-dihydro-4,5-dihydroxy-1-nitropyrene and 1-nitrohydroxypyrenes. Substantial amounts of unknown polar metabolites were also produced by cultured lung. Nitro-reduction to 1-aminopyrene was minimal in mouse lung and liver, even under oxygen deficient conditions.
Author List
El-Bayoumy K, Hecht SS, Sackl T, Stoner GDMESH terms used to index this publication - Major topics in bold
AnimalsFemale
In Vitro Techniques
Liver
Lung Neoplasms
Male
Mice
Mice, Inbred Strains
Mutagens
Oxidation-Reduction
Pyrenes
