Faculty Collaboration Database

Clinical applications of highly sensitive troponin assays. Cardiol Rev 2010;18(1):12-9

Date

12/17/2009

Pubmed ID

20010334

DOI

10.1097/CRD.0b013e3181c42f96

Scopus ID

2-s2.0-74549200560 (requires institutional sign-in at Scopus site)   48 Citations

Abstract

Cardiac troponin is the biomarker of choice for the diagnosis of acute myocardial infarction. Recent consensus recommendations have adopted a concentration of troponin above the 99th percentile of a healthy population to diagnose myocardial infarction. Until recently, there was no assay capable of achieving recommended precision; however, with the development of "highly sensitive" troponin assays, it is now possible to accurately measure troponin concentrations at and below the current 99th percentile of a healthy population. These assays have enormous potential in not only identifying more patients with acute myocardial infarction, and providing superior risk prediction in those so afflicted, in addition highly sensitive troponins assays may be useful for long-term risk assessment of the patient with coronary disease. In this article, we will review the clinical applications, novel concepts, challenges, and limitations of using highly sensitive troponins assays.

Author List

Mohammed AA, Januzzi JL Jr

MESH terms used to index this publication - Major topics in bold

Acute Coronary Syndrome
Angina, Unstable
Biomarkers
Cardiomyopathies
Drug-Related Side Effects and Adverse Reactions
Exercise
Humans
Kidney Failure, Chronic
Myocardial Infarction
Myocardial Ischemia
Sensitivity and Specificity
Troponin T