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Range of ventricular dimensions and function by steady-state free precession cine MRI in repaired tetralogy of Fallot: right ventricular outflow tract patch vs. conduit repair. J Magn Reson Imaging 2007 Oct;26(4):934-40

Date

09/27/2007

Pubmed ID

17896382

DOI

10.1002/jmri.21094

Scopus ID

2-s2.0-35148859470 (requires institutional sign-in at Scopus site)   69 Citations

Abstract

PURPOSE: To characterize the range of biventricular size and function evaluated by steady-state free precession (SSFP) cine magnetic resonance (MR) in a large cohort of patients with repaired tetralogy of Fallot (TOF), and to compare these measurements in those with a right ventricular outflow tract (RVOT) patch vs. a right ventricle-to-pulmonary artery (RV-PA) conduit.

MATERIALS AND METHODS: Analysis of ventricular size and function in 300 consecutive examinations in patients with repaired TOF evaluated by SSFP cine MR.

RESULTS: Of the 300 examinations performed in 256 patients, 69% had undergone repair with a RVOT patch and 31% with a RV-PA conduit. Compared to patients with RV-PA conduit, those with a RVOT patch had significantly more pulmonary regurgitation (PR) (38 +/- 17 vs. 23 +/- 16%, P < 0.0001), larger indexed RV end-diastolic volume (154 +/- 53 vs. 133 +/- 51 mL/m(2), P = 0.002), similar indexed end-systolic volume (80 +/- 39 vs. 74 +/- 46 mL/m(2), P = 0.31), higher ejection fraction (EF) (50 +/- 9 vs. 47 +/- 12%, P = 0.037), and lower mass-to-volume ratio (0.29 +/- 0.08 vs. 0.36 +/- 0.13, P < 0.0001). Pulmonary regurgitation fraction correlated positively with RV end-diastolic volume index in the RVOT patch group (r = 0.51, P < 0.0001) but not in the RV-PA conduit.

CONCLUSION: This study provides the range and distribution of biventricular size and function, and PR measured by MRI in a large contemporary cohort of patients with repaired TOF, and demonstrates important variations in RV mechanics between patients repaired with a RVOT patch and those with an RV-PA conduit.

Author List

Samyn MM, Powell AJ, Garg R, Sena L, Geva T

Author

Margaret Mary Samyn MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Child
Child, Preschool
Cohort Studies
Female
Heart Diseases
Heart Ventricles
Humans
Infant
Infant, Newborn
Magnetic Resonance Imaging
Magnetic Resonance Imaging, Cine
Male
Middle Aged
Pulmonary Artery
Reproducibility of Results
Tetralogy of Fallot