Selective Involvement of the Checkpoint Regulator VISTA in Suppression of B-Cell, but Not T-Cell, Responsiveness by Monocytic Myeloid-Derived Suppressor Cells from Mice Infected with an Immunodeficiency-Causing Retrovirus. J Virol 2015 Sep;89(18):9693-8
Date
07/15/2015Pubmed ID
26157131Pubmed Central ID
PMC4542392DOI
10.1128/JVI.00888-15Scopus ID
2-s2.0-84940469042 (requires institutional sign-in at Scopus site) 45 CitationsAbstract
Inhibition of T-cell responses in tumor microenvironments by myeloid-derived suppressor cells (MDSCs) is widely accepted. We demonstrated augmentation of monocytic MDSCs whose suppression of not only T-cell, but also B-cell, responsiveness paralleled the immunodeficiency during LP-BM5 retrovirus infection. MDSCs inhibited T cells by inducible nitric oxide synthase (iNOS)/nitric oxide (NO), but uniquely, inhibition of B cells was ~50% dependent each on iNOS/NO and the MDSC-expressed negative-checkpoint regulator VISTA. Blockade with a combination of iNOS/NO and VISTA caused additive or synergistic abrogation of MDSC-mediated suppression of B-cell responsiveness.
Author List
Green KA, Wang L, Noelle RJ, Green WRMESH terms used to index this publication - Major topics in bold
AnimalsB-Lymphocytes
Immunologic Deficiency Syndromes
Membrane Proteins
Mice
Monocytes
Nitric Oxide
Nitric Oxide Synthase Type II
Retroviridae Infections
T-Lymphocytes
