High plasma levels of 8-methoxypsoralen following bath water delivery in dermatological patients. Skin Pharmacol Appl Skin Physiol 2003;16(5):305-12
Date
08/09/2003Pubmed ID
12907835DOI
10.1159/000072070Scopus ID
2-s2.0-0042573881 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
With respect to the clinical advantages known for bath PUVA therapy, it was of interest to compare the plasma levels of 8-methoxypsoralen (8-MOP) in bath therapy with those after oral administration for a better insight into the pharmacokinetics of 8-MOP following different modes of application. Considerable high plasma levels of 8-MOP were observed after bath therapy with interindividual variability. The half-life of plasma 8-MOP was markedly shorter after bath PUVA than after oral application. The pharmacokinetic profile of 8-MOP differs according to the mode of application.
Author List
Kappes UP, Barta U, Merkel U, Balogh A, Elsner PMESH terms used to index this publication - Major topics in bold
Administration, CutaneousAdministration, Oral
Adolescent
Adult
Aged
Aged, 80 and over
Area Under Curve
Baths
Biological Availability
Female
Half-Life
Humans
Male
Methoxsalen
Middle Aged
PUVA Therapy
Photosensitizing Agents
Skin Absorption
Skin Diseases
Time Factors
Water
