Tandem application of sodium lauryl sulfate and n-propanol does not lead to enhancement of cumulative skin irritation. Acta Derm Venereol 2001;81(6):403-5
Date
02/28/2002Pubmed ID
11859941DOI
10.1080/000155501317208327Scopus ID
2-s2.0-0035701559 (requires institutional sign-in at Scopus site) 47 CitationsAbstract
Irritant contact dermatitis has a broad spectrum of clinical features and is a leading cause of occupational disease worldwide. It has been shown previously that a combination of chemically different irritants may cause an additive effect compared to single application of these substances. In this study, tandem application of sodium lauryl sulfate and n-propanol was investigated in 20 human volunteers using non-invasive bioengineering methods, such as measurement of transepidermal water loss and chromametry. N-propanol did not enhance cumulative skin irritation when used with sodium lauryl sulfate, as has been reported for toluene. As n-propanol is the active ingredient in many disinfectants, this is of particular interest regarding occupational skin irritation in health care workers.
Author List
Kappes UP, Göritz N, Wigger-Alberti W, Heinemann C, Elsner PMESH terms used to index this publication - Major topics in bold
1-PropanolAdult
Colorimetry
Dermatitis, Irritant
Dermatitis, Occupational
Erythema
Female
Humans
Irritants
Male
Skin
Sodium Dodecyl Sulfate
Water Loss, Insensible
