Faculty Collaboration Database

Short-term effects of treatment with simvastatin on testicular function in patients with heterozygous familial hypercholesterolaemia. Eur J Clin Pharmacol 1992;42(1):61-4

Date

01/01/1992

Pubmed ID

1541317

DOI

10.1007/BF00314921

Scopus ID

2-s2.0-0026604874 (requires institutional sign-in at Scopus site)   42 Citations

Abstract

The effects of simvastatin 40 mg per day for 14 weeks on the pituitary-testis axis of 19 men with familial hypercholesterolaemia have been examined in a single-blind study. Simvastatin significantly reduced serum low density lipoprotein (LDL) cholesterol and triglycerides by 45% and 30%, respectively, and significantly increased high density lipoprotein (HDL) cholesterol by 15%. The alterations, which were stable 4 weeks after the start of treatment, were not associated with any significant change in sperm quality, the seminal plasma concentrations of various sex gland products (prostate-specific acid phosphatase, polyamines, citrate, fructose, alpha-glucosidase), or the serum concentrations of cortisol, testosterone, LH, FSH, or prolactin. It is concluded that a short-term reduction in circulating LDL-cholesterol has no marked effect on testicular function or sperm quality.

Author List

Purvis K, Tollefsrud A, Rui H, Haug E, Norseth J, Viksmoen L, Ose L, Lund H

MESH terms used to index this publication - Major topics in bold

Adult
Anticholesteremic Agents
Heterozygote
Hormones
Humans
Hyperlipoproteinemia Type II
Lovastatin
Male
Middle Aged
Simvastatin
Single-Blind Method
Spermatozoa
Testis