Hormonal activation of the adenylyl cyclases of the rat and human prostate gland. Prostate 1986;8(1):11-24
Date
01/01/1986Pubmed ID
2418428DOI
10.1002/pros.2990080104Scopus ID
2-s2.0-0022623178 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
The rat ventral prostate and the human hyperplastic prostate contain adenylyl cyclases which can be activated by a variety of neurotransmittors, including vasoactive intestinal peptide (VIP), beta 2 adrenergic agonists, and dopamine. In both species the response to VIP was predominantly localized to the epithelial fraction. In the human tissue activation of the enzyme could also be achieved with prostaglandin E1 (PGE1) and an alpha 2 adrenergic agonist both associated with the stromal compartment. Castration in the rat caused a marked reduction in the basal activity of the enzyme and the maximal level of the hormone-stimulated response per cell (per mg DNA), but had only minor effects on the pattern of activation when expressed per mg membrane protein. Androgen treatment (dihydrotestosterone propionate, 2.5 mg/day) prevented the castration effects. Estrogen treatment (estradiol benzoate, 125 micrograms/day) could not prevent the castrational changes but maintained enzyme activity at a level above that of the castrate. There were no major qualitative differences in the pattern of activation of the cyclase between the different lobes of the rat prostate and the seminal vesicle.
Author List
Purvis K, Rui H, Gordeladze JO, Attramadal HMESH terms used to index this publication - Major topics in bold
Adenylyl CyclasesAlprostadil
Animals
Clonidine
Dopamine
Enzyme Activation
Histamine
Humans
Isoproterenol
Male
Orchiectomy
Propanolamines
Prostate
Prostatic Hyperplasia
Rats
Rats, Inbred Strains
Seminal Vesicles
Terbutaline
Vasoactive Intestinal Peptide
