Short-term effects of prolactin on prostatic function in rats with lisuride-induced hypoprolactinaemia. J Reprod Fertil 1985 Nov;75(2):421-32
Date
11/01/1985Pubmed ID
4067923DOI
10.1530/jrf.0.0750421Scopus ID
2-s2.0-0022351746 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
The effects of a single injection of ovine prolactin on prostatic function were monitored in intact, intact androgenized and castrated-androgenized rats rendered hypoprolactinaemic after 7 days of treatment with a potent dopamine agonist, lisuride. Hypoprolactinaemia was associated with reductions in ventral prostate weight, polyamine levels, lateral lobe zinc and the concentration of the ventral prostate protein prostatein, but an elevation in the level of cytosolic oestradiol binding. Whether these differences attained statistical significance depended on whether the animals were intact, intact-androgenized or castrated-androgenized. With the exception of ventral prostate weight and lateral lobe zinc concentrations, a single injection of prolactin restored or reversed these changes towards control levels within 12 h, which could not be explained by an indirect effect of the hormone on adrenal or testicular function. No effects of lisuride or prolactin were observed with regard to the content of fructose in the coagulating gland or in the degree of prolactin binding to prostatic membranes.
Author List
Rui H, Haug E, Mevåg B, Thomassen Y, Purvis KMESH terms used to index this publication - Major topics in bold
Androgen-Binding ProteinAnimals
Circadian Rhythm
Cytosol
Ergolines
Estradiol
Lisuride
Luteinizing Hormone
Male
Orchiectomy
Organ Size
Prolactin
Prostate
Prostatein
Rats
Secretoglobins
Testosterone
Time Factors
Uteroglobin
