Thymomas II: a clinicopathologic correlation of 250 cases with a proposed staging system with emphasis on pathologic assessment. Am J Clin Pathol 2012 Mar;137(3):451-61
Date
02/18/2012Pubmed ID
22338058DOI
10.1309/AJCP36ALGUZWOSEAScopus ID
2-s2.0-84859258577 (requires institutional sign-in at Scopus site) 54 CitationsAbstract
We present 250 cases of thymomas with emphasis on their clinical staging and follow-up. The patients were 120 males and 130 females between the ages of 13 and 92 years. Surgical resection was performed and histopathologic material evaluated in every case. Grossly, the tumors resected varied in size from 3 to 20 cm in greatest diameter. According to our proposed staging system, 31 cases were stage 0, 128 were stage I, 70 stage II, and 21 stage III at the time of resection. Histologically, approximately 53% of thymomas were of mixed histologic types. Follow-up information ranging from 1 to 16 years was obtained, showing significant statistical P values of .044 and .016 for overall and recurrence-free survival, respectively. We consider that our proposed staging system offers better stratification of cases and improved histologic definitions for proper staging of cases of thymoma.
Author List
Moran CA, Walsh G, Suster S, Kaiser LMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Aged, 80 and over
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Neoplasms, Multiple Primary
Survival Rate
Thymectomy
Thymoma
Thymus Neoplasms
Young Adult
