Thymomas I: a clinicopathologic correlation of 250 cases with emphasis on the World Health Organization schema. Am J Clin Pathol 2012 Mar;137(3):444-50
Date
02/18/2012Pubmed ID
22338057DOI
10.1309/AJCP76KEGWQKWOKAScopus ID
2-s2.0-84859247108 (requires institutional sign-in at Scopus site) 72 CitationsAbstract
We describe 250 cases of thymoma with emphasis on World Health Organization (WHO) histologic subtyping. The patients were 120 males and 130 females between the ages of 13 and 92 years. Surgical resection was performed, and histologic material was evaluated in every case. Macroscopically, the tumors varied in size from 3 to 20 cm in greatest diameter; about 12% were encapsulated, and about 88% were invasive tumors. A minimum of 5 sections of tumor was evaluated. Histologically, following the schema proposed by the WHO, 21.6% of thymomas were type A, 1.23% type B1, 3.2% type B2, and 9.2% type B3. More than 50% of tumors after subtyping fell into the mixed categories, which, in essence, diminishes the clinical impact of histologic subtyping over staging. The study herein described highlights that all thymomas had the potential to become invasive tumors.
Author List
Moran CA, Weissferdt A, Kalhor N, Solis LM, Behrens C, Wistuba II, Suster SMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Aged, 80 and over
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Neoplasm Staging
Survival Rate
Texas
Thymectomy
Thymoma
Thymus Neoplasms
World Health Organization
Young Adult
