Faculty Collaboration Database

Invasive spindle cell thymomas (WHO Type A): a clinicopathologic correlation of 41 cases. Am J Clin Pathol 2010 Nov;134(5):793-8

Date

10/21/2010

Pubmed ID

20959663

DOI

10.1309/AJCP7KBP4QQLRLXW

Scopus ID

2-s2.0-78049505111 (requires institutional sign-in at Scopus site)   37 Citations

Abstract

We report 41 cases of invasive spindle cell thymomas (World Health Organization type A). The patients were 16 women and 25 men between the ages of 38 and 80 years. Clinically, the patients had diverse symptomatology, including chest pain, cough, and dyspnea. None of the patients had a history of myasthenia gravis. According to the Mazaoka surgical staging system, 34 patients had stage II disease, 6 had stage III, and 1 had stage IV. Follow-up information showed that 30 patients were alive after a period ranging from 12 to 96 months; for 8 patients who are alive, the follow-up was less than 12 months; 1 patient died 10 months after initial diagnosis. For 2 patients, no follow-up information was obtained. This study stresses the fact that histologic features do not correlate with invasion or encapsulation because all thymomas, regardless of their histologic type, are capable of invasion.

Author List

Moran CA, Kalhor N, Suster S

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Neoplasm Staging
Thymoma
Thymus Neoplasms