Micropapillary urothelial carcinoma of the upper urinary tract: Clinicopathologic study of five cases. Am J Clin Pathol 2006 Jul;126(1):86-92
Date
06/07/2006Pubmed ID
16753597DOI
10.1309/K7ME-LVFP-KQE2-RCDLScopus ID
2-s2.0-33745793001 (requires institutional sign-in at Scopus site) 38 CitationsAbstract
We report 5 cases of micropapillary urothelial carcinoma (MPUC) involving the renal pelvis (2), renal pelvis and ureter (2), and proximal ureter (1). The patients were 2 women and 3 men, ages 65 to 92 years (mean, 76.0 years). All tumors showed a high-grade transitional cell carcinoma component, and in 3 cases, there also were areas of in situ carcinoma. The case involving only the ureter occurred in a 65-year-old man with a history of nephrectomy 12 years previously for urothelial carcinoma of the renal pelvis. The tumor recurred in the ureteral stump. In all cases, areas displaying micropapillary architecture were observed. In 2 cases the micropapillary areas were noninvasive; in 1 case a pure invasive pattern was seen; and in 2 cases a mixed invasive and noninvasive pattern was present. the micropapillary pattern was invasive; and the case involving the ureteral stump contained invasive and noninvasive micropapillary carcinoma. All patients died of their tumors from 3 to 24 months after initial diagnosis. MPUC involving the renal pelvis and ureter is associated closely with advanced stages of disease and has highly aggressive behavior. Recognition of this growth pattern is important for prognosis and avoiding misdiagnosis with papillary renal cell carcinoma and other tumors.
Author List
Perez-Montiel D, Hes O, Michal M, Suster SMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Biomarkers, Tumor
Carcinoma in Situ
Carcinoma, Renal Cell
Carcinoma, Transitional Cell
Fatal Outcome
Female
Humans
Kidney Pelvis
Male
Neoplasm Recurrence, Local
Ureter
Ureteral Neoplasms
Urothelium
