Pulmonary artery sarcoma: a clinicopathologic and immunohistochemical study of 12 cases. Am J Clin Pathol 2006 Mar;125(3):419-24
Date
04/15/2006Pubmed ID
16613346Scopus ID
2-s2.0-33644638805 (requires institutional sign-in at Scopus site) 96 CitationsAbstract
We report 12 cases of pulmonary artery sarcoma. The mean age at diagnosis was 48.4 years. Based on histomorphologic features and immunohistochemical findings, 2 tumors were classified as rhabdomyosarcoma, 4 as leiomyosarcoma, 1 as osteogenic sarcoma, 1 as angiosarcoma, and 4 as high-grade sarcoma. All patients underwent surgery. In addition, 7 patients received neoadjuvant or adjuvant therapy. Five patients died 3 to 23 months after surgery. Three patients were still alive at 8, 27, and 68 months at last follow-up. Another 3 patients were alive at 2, 15, and 40 months and then lost to follow-up. The 2 patients with the longest survival (40 months and 68 months) had a diagnosis of leiomyosarcoma. Both patients with rhabdomyosarcoma died at 3 months after surgery. Pulmonary artery sarcoma is an uncommon entity with a poor prognosis. The role of early diagnosis, histologic classification, surgical treatment, and adjuvant therapy in patient outcome is discussed.
Author List
Huo L, Moran CA, Fuller GN, Gladish G, Suster SMESH terms used to index this publication - Major topics in bold
AdultAged
Biomarkers, Tumor
Combined Modality Therapy
Fatal Outcome
Female
Humans
Immunohistochemistry
Male
Middle Aged
Pulmonary Artery
Radiography
Sarcoma
Vascular Neoplasms
