Faculty Collaboration Database

CDX2 is a useful marker of intestinal-type differentiation: a tissue microarray-based study of 629 tumors from various sites. Arch Pathol Lab Med 2005 Sep;129(9):1100-5

Date

08/27/2005

Pubmed ID

16119980

DOI

10.5858/2005-129-1100-CIAUMO

Scopus ID

2-s2.0-24144498763 (requires institutional sign-in at Scopus site)   101 Citations

Abstract

CONTEXT: CDX2, a critical nuclear transcription factor for intestinal development, is expressed in intestinal epithelium and adenocarcinomas.

OBJECTIVES: To determine if CDX2 is a useful marker for intestinal-type differentiation and to correlate tumor histology with CDX2 staining in colorectal adenocarcinomas.

DESIGN: Tissue microarrays from 71 colorectal adenocarcinomas, 31 hepatocellular carcinomas, 47 lung adenocarcinomas, 55 squamous cell carcinomas of the lung, 69 neuroendocrine carcinomas of the lung and 43 of the pancreas, 57 pancreatic adenocarcinomas, and 256 endometrial adenocarcinomas were stained with antibody against CDX2.

RESULTS: CDX2 staining was positive in 51 (71.8%) of 71 colorectal cancers, including 38 (74.5%) of 51 well- or moderately differentiated tumors and 13 (65.0%) of 20 high-grade tumors. Of the high-grade tumors, 5 (71.4%) of 7 mucinous, 3 (100%) of 3 signet ring cell, and 5 (50.0%) of 10 poorly differentiated tumors were positive. Other tumors showing occasional CDX2 staining included 1 of 30 well- or moderately differentiated neuroendocrine carcinomas of the lung and 2 of 43 from the pancreas, 1 of 47 lung adenocarcinomas, 3 of 57 pancreatic adenocarcinomas, and 15 of 256 endometrial carcinomas. Hepatocellular, poorly differentiated neuroendocrine carcinoma of the lung and squamous cell carcinomas of the lung were not immunoreactive for CDX2.

CONCLUSIONS: CDX2 is a useful marker for intestinal-type differentiation, is rarely seen in tumors from the other sites evaluated, and may be useful in determining the site of origin for some metastatic tumors. However, CDX2 is not a sensitive marker for poorly differentiated colorectal carcinoma.

Author List

De Lott LB, Morrison C, Suster S, Cohn DE, Frankel WL

MESH terms used to index this publication - Major topics in bold

Adenocarcinoma
Biomarkers, Tumor
CDX2 Transcription Factor
Cell Transformation, Neoplastic
Colorectal Neoplasms
Female
Histocytological Preparation Techniques
Homeodomain Proteins
Humans
Immunoenzyme Techniques
Intestinal Mucosa
Neoplasms
Protein Array Analysis