Pulmonary metastasis from liposarcoma: a clinicopathologic and immunohistochemical study of 24 cases. Am J Clin Pathol 2005 Feb;123(2):265-75
Date
04/22/2005Pubmed ID
15842053DOI
10.1309/blym-30cd-jjc6-g1nqScopus ID
2-s2.0-13244287885 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
A review of the histologic features of pulmonary metastasis and clinical implications of liposarcoma (LS) is given for 24 cases (8 each) of the 3 types of LS: myxoid LS (ML), pleomorphic LS (PL), and dedifferentiated LS (DDL). Most patients were men. Metastatic ML and PL were distributed almost equally among the lung lobes, whereas DDL was more common in the left lower lobe. The metastatic MLs had variable cellularity ranging from singly scattered cells in a hyalinized stroma (treatment-related effect) to hypercellular ML. Most PLs (6/8) were nonlipogenic and resembled an undifferentiated pleomorphic sarcoma. All metastatic DDLs had high-grade histologic features and were predictably nonlipogenic. After pulmonary metastasectomy, 2 patients with ML and 1 with PL were disease-free. The other 6 patients with ML, 7 with PL, and all with DDL had progressive disease. The morphologic features of LS metastatic to the lungs seem diverse but within the spectrum of the histologic type expected from the primary tumor. Overall, the general trend for these LS subsets is progressive disease, metastatic disease for ML and PL with a much shorter interval for PL, and metastatic disease and local recurrence for DDL.
Author List
Nicolas M, Moran CA, Suster SMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Biomarkers, Tumor
Combined Modality Therapy
Female
Humans
Immunohistochemistry
Liposarcoma
Lung Neoplasms
Male
Middle Aged
Neoplasm Recurrence, Local
Soft Tissue Neoplasms
