Faculty Collaboration Database

The Time to Weight-Loss Steady State After Gastric Bypass Predicts Weight-Loss Success. Obes Surg 2016 Feb;26(2):327-31

Date

06/10/2015

Pubmed ID

26055551

DOI

10.1007/s11695-015-1754-z

Scopus ID

2-s2.0-84930608719 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

BACKGROUND: There is marked variability in weight loss achieved after laparoscopic Roux-en-Y gastric bypass (LRYGB) with little ability to predict pre-operatively poor weight-loss outcomes. In this study, we categorize the patterns of post-operative weight loss after LRYGB by using a novel method of measurement based on the time to weight-loss steady state (SS).

METHODS: A bariatric database was retrospectively reviewed for patients who underwent a LRYGB from 01/2001-12/2010. SS was defined as the month when the patient had ≤3% excess weight loss (%EWL) or weight gain from the prior visit. Percent total weight loss (%TWL) and %EWL were compared based on time to SS.

RESULTS: The average time to SS was 15.5 months (n = 178). A percentage of 7.3 of patients lost >5%EWL after achieving their SS weight. Patients with SS <12 months (n = 47) had a significantly lower %TWL and %EWL at SS and a 3-4-year follow-up compared to SS ≥12 months (n = 131, p < 0.05 for all). Initial weight loss velocity (IWLV) and body mass index (BMI) were not significantly associated with the time to SS. Patients with a SS <12 months were significantly older than patients with SS ≥months (42.7 ± 10.5 versus 46.5 ± 11.8 years, p = 0.05).

CONCLUSIONS: Few patients achieve meaningful weight loss after SS. The time to SS varies significantly among LRYGB patients and is not predicted by the IWLV or BMI. Achievement of SS within the first year after surgery is more common with increasing age and may represent rapid physiologic adaptation with significantly lower %TWL and %EWL.

Author List

Kindel T, Lomelin D, McBride C, Kothari V, Thompson J

Author

Tammy Lyn Kindel MD, PhD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adaptation, Physiological
Adult
Body Mass Index
Databases, Factual
Female
Gastric Bypass
Humans
Laparoscopy
Male
Middle Aged
Obesity, Morbid
Postoperative Period
Retrospective Studies
Time Factors
Treatment Outcome
Weight Gain
Weight Loss