Programmed regulation of rat offspring adipogenic transcription factor (PPARγ) by maternal nutrition. J Dev Orig Health Dis 2015 Dec;6(6):530-8
Date
08/20/2015Pubmed ID
26286138Pubmed Central ID
PMC4630004DOI
10.1017/S2040174415001440Scopus ID
2-s2.0-84945448991 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
We determined the protein expression of adipogenic transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ) and its co-repressor and co-activator complexes in adipose tissue from the obese offspring of under- and over-nourished dams. Female rats were fed either a high-fat (60% kcal) or control (10% kcal) diet before mating, and throughout pregnancy and lactation (Mat-OB). Additional dams were 50% food-restricted from pregnancy day 10 to term [intrauterine growth-restricted (IUGR)]. Adipose tissue protein expression was analyzed in newborn and adult male offspring. Normal birth weight Mat-OB and low birth weight IUGR newborns had upregulated PPARγ with variable changes in co-repressors and co-activators. As obese adults, Mat-OB and IUGR offspring had increased PPARγ with decreased co-repressor and increased co-activator expression. Nutritionally programmed increased PPARγ expression is associated with altered expression of its co-regulators in the newborn and adult offspring. Functional studies of PPARγ co-regulators are necessary to establish their role in PPARγ-mediated programmed obesity.
Author List
Desai M, Jellyman JK, Han G, Lane RH, Ross MGMESH terms used to index this publication - Major topics in bold
Adipose TissueAnimals
Birth Weight
Blood Glucose
Body Size
Diet, High-Fat
Female
Gene Expression Regulation, Developmental
Insulin
Maternal Nutritional Physiological Phenomena
PPAR gamma
Rats
Triglycerides
