The effect of earlier puberty on cardiometabolic risk factors in Afro-Caribbean children. J Pediatr Endocrinol Metab 2014 May;27(5-6):453-60
Date
01/29/2014Pubmed ID
24468602DOI
10.1515/jpem-2013-0324Scopus ID
2-s2.0-84902488533 (requires institutional sign-in at Scopus site) 23 CitationsAbstract
An earlier onset of puberty is associated with increased cardiometabolic risk. We investigated whether this relation was independent of faster childhood growth or current size in an Afro-Caribbean birth cohort (n=259). Anthropometry was measured at birth and then 6-monthly. Tanner staging started at age 8 years. Cardiometabolic risk factors were measured at mean age 11.5 years. In boys, pubarchal stage and testicular size were associated with lower high-density lipoprotein cholesterol, higher systolic blood pressure, and higher homeostasis model assessment of insulin resistance score, but not after adjusting for current body mass index (BMI) or rate of growth (up to age 8 years). In girls, earlier menarche and greater breast development were associated with higher fasting glucose even after adjusting for current BMI or prior growth. Pubarchal stage was associated with systolic blood pressure, even after adjusting for current BMI and prior growth. We concluded that earlier puberty is independently associated with cardiometabolic risk in girls but not in boys.
Author List
Boyne MS, Thame M, Osmond C, Fraser RA, Gabay L, Taylor-Bryan C, Forrester TEMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Blood Glucose
Blood Pressure
Child
Cohort Studies
Female
Heart Diseases
Humans
Insulin Resistance
Jamaica
Lipids
Male
Pregnancy
Puberty
Puberty, Precocious
Risk Factors
Sex Distribution
Young Adult
