Repertoire of microglial and macrophage responses after spinal cord injury. Nat Rev Neurosci 2011 Jun 15;12(7):388-99
Date
06/16/2011Pubmed ID
21673720DOI
10.1038/nrn3053Scopus ID
2-s2.0-79959379095 (requires institutional sign-in at Scopus site) 1261 CitationsAbstract
Macrophages from the peripheral circulation and those derived from resident microglia are among the main effector cells of the inflammatory response that follows spinal cord trauma. There has been considerable debate in the field as to whether the inflammatory response is good or bad for tissue protection and repair. Recent studies on macrophage polarization in non-neural tissues have shed much light on their changing functional states. In the context of this literature, we discuss the activation of macrophages and microglia following spinal cord injury, and their effects on repair. Harnessing their anti-inflammatory properties could pave the way for new therapeutic strategies for spinal cord trauma.
Author List
David S, Kroner AAuthor
Antje Kroner-Milsch PhD, MD Associate Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCell Polarity
Humans
Inflammation
Macrophages
Microglia
Models, Biological
Spinal Cord Injuries
