Isolated abnormal strict morphology is not a contraindication for intrauterine insemination. Andrology 2015 Nov;3(6):1088-93
Date
09/20/2015Pubmed ID
26384603DOI
10.1111/andr.12098Scopus ID
2-s2.0-84957426547 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
This study sought to investigate whether isolated abnormal strict morphology (<5% normal forms) and very low strict morphology (0-1% normal forms) affects pregnancy rates in intrauterine insemination (IUI). This was a retrospective study performed at an Academic Medical Center/Reproductive Medicine Center. Four hundred and eight couples were included for 856 IUI cycles. 70 IUI cycles were performed in couples with abnormal strict morphology and otherwise normal semen parameters. Outcomes were measured as clinical pregnancy rate per IUI cycle as documented by fetal heart activity on maternal ultrasound. Clinical pregnancy rate did not significantly differ between the group with abnormal strict morphology [11/70 (15.7%)] and the normal morphology group [39/281 (13.9%)]. Additionally, there was no significant difference between the pregnancy rate in the abnormal morphology group compared to that of our overall institutional IUI pregnancy rate [145/856 (16.9%)]. Furthermore, there was no significant difference between pregnancy rate in the very low morphology group [3/14 (21.4%)] compared to those with normal morphology or the overall IUI pregnancy rate. Patients with isolated abnormal strict morphology have clinical pregnancy rates similar to those with normal morphology for IUI. Even in those with very low normal forms, consideration of IUI for assisted reproduction should not be excluded.
Author List
Lockwood GM, Deveneau NE, Shridharani AN, Strawn EY, Sandlow JIAuthor
Jay I. Sandlow MD Chair, Professor in the Urologic Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultFemale
Humans
Infertility, Male
Insemination, Artificial, Homologous
Male
Predictive Value of Tests
Pregnancy
Pregnancy Rate
Retrospective Studies
Risk Factors
Semen Analysis
Spermatozoa
Treatment Outcome
